Alex Tong
Alex Tong
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flow-matching
SE(3)-Stochastic Flow Matching for Protein Backbone Generation
We present
FoldFlow
a novel flow matching model for protein design. We present theory and practical tricks for flow models over SE(3)^N. Empirically, we validate these models on protein backbone generation of up to 300 amino acids leading to high-quality designable, diverse, and novel samples.
Avishek Joey Bose
,
Tara Akhound-Sadegh
,
Kilian Fatras
,
Guillaume Huguet
,
Jarrid Rector-Brooks
,
Cheng-Hao Liu
,
Andrei Cristian Nica
,
Maksym Korablyov
,
Michael Bronstein
,
Alex Tong
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